Open .smi Files Online — Free SMILES Viewer
Open SMILES File Online — Free & Instant
No signup required. Works in your browser.
📁 Drag & drop your file here
or click to browse • Max 100MB
✅ Free • ⚡ Instant • 🔒 Secure • 💻 No install
What Is a .smi File?
A .smi file is a scientific format known as SMILES. SMILES Chemical Notation This format is created by Daylight and is widely used by researchers and academics.
SMILES files contain structured scientific data that requires compatible software to open. With OpenAnyFile, you can analyze and visualize .smi files directly in your browser without installing any software.
How to Open .smi Files Online
- Visit OpenAnyFile SMILES page
- Drag and drop your .smi file onto the upload area, or click "Browse" to select it
- OpenAnyFile automatically detects the SMILES format using magic byte analysis
- View, analyze, and analyze and visualize your file contents in the browser
- Optionally convert to MOL, SDF, SVG or download
Software That Opens .smi Files
.smi files are primarily created by Daylight. In the scientific space, you may encounter .smi files from third-party tools, online converters, or export functions. Regardless of the source, OpenAnyFile handles them all.
Open .smi on Different Platforms
- Windows: Use the original software or upload to OpenAnyFile for instant access
- macOS: Preview may not support .smi — use OpenAnyFile as a universal viewer
- Linux: Open-source alternatives exist, or use OpenAnyFile in any browser
- Mobile (iPhone/Android): OpenAnyFile works on all mobile browsers
Common .smi File Problems
Canonicalization differences
Other common issues include: your OS not recognizing the file extension, the file appearing corrupted after download, or lacking the required software. OpenAnyFile bypasses all these issues with universal format detection.
Convert SMILES to Other Formats
SMILES files can be converted to 3 formats including MOL, SDF, SVG.
Related Scientific Formats
If you work with .smi files, you may also encounter these scientific formats:
- ABAQUS_INP (.inp) — Open & convert .inp files online
- ABF (.abf) — Open & convert .abf files online
- ABINIT (.abi) — Open & convert .abi files online
- AMBER (.prmtop) — Open & convert .prmtop files online
- Amber Topology (prmtop) — Open & convert prmtop files online
- Amber Trajectory (mdcrd) — Open & convert mdcrd files online
- ANSYS_MECH (.mechdat) — Open & convert .mechdat files online
- ANTEX (.atx) — Open & convert .atx files online
- ASC_LTSPICE (.asc) — Open & convert .asc files online
- ASYMPTOTE (.asy) — Open & convert .asy files online
Popular SMILES Conversions
Frequently Asked Questions
What is a .smi file?
A .smi file is a scientific format called SMILES. SMILES Chemical Notation
How do I open a .smi file without installing software?
Upload your .smi file to OpenAnyFile. Our browser-based tool instantly detects and displays it — no downloads needed.
What program creates .smi files?
.smi files are typically created by Daylight.
Can I convert .smi to another format?
Yes. OpenAnyFile converts .smi to MOL, SDF, SVG.
Is it safe to open .smi files online?
Yes. OpenAnyFile processes files in a secure, isolated environment. Files are automatically deleted and all transfers use HTTPS.
Can I open .smi on my phone?
Yes. OpenAnyFile works on all mobile browsers including iPhone and Android.