SMILES File — Open & Convert .smi Online
What Is a .smi File?
SMILES (.smi) is a scientific file format. SMILES Chemical Notation Created by Daylight, this format is essential for researchers and academics.
How to Open .smi Files
Upload your .smi file to OpenAnyFile and instantly analyze and visualize it in your browser. No software installation required. Works on Windows, macOS, Linux, iPhone, and Android.
Everything About SMILES Files
Popular SMILES Conversions
Frequently Asked Questions
What is a .smi file?
A .smi file is a scientific format called SMILES. SMILES Chemical Notation
How do I open a .smi file without installing software?
Upload your .smi file to OpenAnyFile. Our browser-based tool instantly detects and displays it — no downloads needed.
What program creates .smi files?
.smi files are typically created by Daylight.
Can I convert .smi to another format?
Yes. OpenAnyFile converts .smi to MOL, SDF, SVG.
Is it safe to open .smi files online?
Yes. OpenAnyFile processes files in a secure, isolated environment. Files are automatically deleted and all transfers use HTTPS.
Can I open .smi on my phone?
Yes. OpenAnyFile works on all mobile browsers including iPhone and Android.